p44: combination therapies after traumatic brain injury by bumetanide and dexamethasone administration a hypothesis study
نویسندگان
چکیده
traumatic brain injury (tbi) initiates a cascade of numerous pathophysiological events that evolve over time. despite the complexity of tbi, research aimed at therapy development has almost exclusively focused on single therapies, all of which have failed in multicenter clinical trials. a variety of brain insults, including traumatic brain injury, encephalitis, stroke, and status epilepticus (se), have the potential to induce the development of epilepsy, particularly temporal lobe epilepsy (tle) in humans and rodent models of tle. the mechanisms underlying this process, which is termed epileptogenesis, are only incompletely understood, but include inflammation, neurodegeneration, blood–brain barrier disruption, alterations in expression and function of diverse receptors and ion channels, and development of hyperexcitability of neurons and neuronal circuits. the goal of the present study was to directly address this hypothesis by treating rats with the nkcc1 inhibitor bumetanide after a tbi. for the present experiments, wistar rats, weighing 200–230 gr must be used. as previous studies on animal model of tbi treat by co-administration of dose dependent bumetanide and dexamethasone. predict result: the result may show dexamethasone can inhibition second injury also combination of these two drugs may have reduction and inhibition of neural injury and inflammatory process. co-administration of dose dependent bumetanide and dexamethasone may have therapeutic role in traumatic brain injury.
منابع مشابه
P44: Combination Therapies after Traumatic Brain Injury by Bumetanide and Dexamethasone Administration a Hypothesis Study
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملP58: Neurological Outcomes after Traumatic Brain Injury Affected by Concomitant Administration of Progesterone and Erythropoietin
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملW1: Neural Tissue Engineering Strategies in Traumatic Brain Injury Therapies
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملPersistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis.
Traumatic brain injury (TBI) represents a significant cause of death and disability in industrialized countries. Of particular importance to patients the chronic effect that TBI has on cognitive function. Therapeutic strategies have been difficult to evaluate because of the complexity of injuries and variety of patient presentations within a TBI population. However, pharmacotherapies targeting ...
متن کاملp58: neurological outcomes after traumatic brain injury affected by concomitant administration of progesterone and erythropoietin
traumatic brain injury (tbi) is one of the most common neurological diseases with no definite treatment. erythropoietin (epo) and progesterone (prog) have been shown to have neuroprotective effects in different types of experimental brain injury models. this study was designed to determine the effect of epo, prog and combination of epo/prog on neurological outcome after traumatic brain injury. ...
متن کاملP83: Enhancement of Seizure Incidence after Traumatic Brain Injury
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
مجله علوم اعصاب شفای خاتمجلد ۲، شماره ۴، صفحات ۹۴-۹۴
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023